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Changes between Initial Version and Version 1 of WhatizitAsTurtle

Timestamp:: 2010/02/10 09:49:15 (15 years ago)
Author:: alabarga
Comment:: --

Legend:

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: Removed
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WhatizitAsTurtle

v1	v1
	1	@prefix chebi: <http://purl.org/obo/owl/CHEBI#CHEBI_> .
	2	@prefix commons: <http://purl.org/commons/> .
	3	@prefix dc: <http://purl.org/dc/elements/1.1/> .
	4	@prefix dcterms: <http://purl.org/dc/terms/> .
	5	@prefix ex: <http://purl.org/example/> .
	6	@prefix foaf: <http://xmlns.com/foaf/0.1/> .
	7	@prefix go: <http://purl.org/obo/owl/GO#GO_> .
	8	@prefix obi: <http://obi.sourceforge.net/ontology/OBI.owl#> .
	9	@prefix obo_interactomics: <http://purl.org/zen/obo_interactomics.owl#> .
	10	@prefix pmid: <http://purl.org/commons/record/pmid/> .
	11	@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
	12	@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
	13	@prefix ro: <http://www.obofoundry.org/ro/ro.owl#> .
	14	@prefix sc: <http://purl.org/science/owl/sciencecommons/> .
	15	@prefix sioc: <http://rdfs.org/sioc/ns#> .
	16	@prefix uniprot: <http://purl.org/commons/record/uniprotkb/> .
	17	@prefix xhv: <http://www.w3.org/1999/xhtml/vocab#> .
	18	@prefix xml: <http://www.w3.org/XML/1998/namespace> .
	19	@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
	20
	21
	22	<http://whatizit.neurocommons.org/index.py/text_query?pipeline=whatizitEBIMedDiseaseChemicals&query=IL-5&format=atag&max_results=10> xhv:stylesheet <http://whatizit.neurocommons.org/creativecommons.css> ;
	23	rdfs:seeAlso
	24	<http://purl.org/commons/html/pmid/10880230>,
	25	<http://purl.org/commons/html/pmid/11159044>,
	26	<http://purl.org/commons/html/pmid/11498591>,
	27	<http://purl.org/commons/html/pmid/11606047>,
	28	<http://purl.org/commons/html/pmid/12969637>,
	29	<http://purl.org/commons/html/pmid/15534922>,
	30	<http://purl.org/commons/html/pmid/16217591>,
	31	<http://purl.org/commons/html/pmid/17282969>,
	32	<http://purl.org/commons/html/pmid/18410960>,
	33	<http://purl.org/commons/html/pmid/8630733>,
	34	<http://purl.org/commons/record/pmid/10880230>,
	35	<http://purl.org/commons/record/pmid/11159044>,
	36	<http://purl.org/commons/record/pmid/11498591>,
	37	<http://purl.org/commons/record/pmid/11606047>,
	38	<http://purl.org/commons/record/pmid/12969637>,
	39	<http://purl.org/commons/record/pmid/15534922>,
	40	<http://purl.org/commons/record/pmid/16217591>,
	41	<http://purl.org/commons/record/pmid/17282969>,
	42	<http://purl.org/commons/record/pmid/18410960>,
	43	<http://purl.org/commons/record/pmid/8630733>,
	44	<http://purl.org/commons/xml/pmid/10880230>,
	45	<http://purl.org/commons/xml/pmid/11159044>,
	46	<http://purl.org/commons/xml/pmid/11498591>,
	47	<http://purl.org/commons/xml/pmid/11606047>,
	48	<http://purl.org/commons/xml/pmid/12969637>,
	49	<http://purl.org/commons/xml/pmid/15534922>,
	50	<http://purl.org/commons/xml/pmid/16217591>,
	51	<http://purl.org/commons/xml/pmid/17282969>,
	52	<http://purl.org/commons/xml/pmid/18410960>,
	53	<http://purl.org/commons/xml/pmid/8630733> .
	54
	55	<pmid:10880230> dc:creator "C J Sanderson", "J Holland", "P E Czabotar" ;
	56	dc:date "Jul 2000" ;
	57	dc:publisher "Cytokine" ;
	58	dc:title """
	59
	60	Identification of regions within the third FnIII-like domain of the
	61	<a href="http://uniprot.org/uniprot/?query=P21183+or+Q01344" xmlns="http://www.w3.org/1999/xhtml">IL-5Ralpha</a> involved in
	62	<a href="http://uniprot.org/uniprot/?query=O02699+or+O08987+or+O77515+or+P04401+or+P05113+or+P46685+or+P48093+or+P52173+or+Q08125+or+Q28586+or+Q62575+or+Q95J76+or+Q9ESI9+or+Q9XT91" xmlns="http://www.w3.org/1999/xhtml">IL-5</a> interaction
	63	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:95]" content="Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.uniprot.org/uniprot/P21183" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q01344" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O02699" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O08987" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O77515" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P04401" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P05113" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P46685" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P48093" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P52173" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q08125" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q28586" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q62575" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q95J76" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9ESI9" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9XT91" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	64
	65	<pmid:11159044> dc:creator
	66	"B P Monia",
	67	"C Walker",
	68	"E Lach-Trifilieff",
	69	"J G Karras",
	70	"R A McKay" ;
	71	dc:date "Feb 2001" ;
	72	dc:publisher "American journal of respiratory cell and molecular biology" ;
	73	dc:title """
	74
	75
	76	<a href="http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30430" xmlns="http://www.w3.org/1999/xhtml">In</a> vitro and in vivo
	77	<a href="http://obofoundry.org/obo/REX:0000218" xmlns="http://www.w3.org/1999/xhtml">inhibition</a> of interleukin (IL)-5-mediated eosinopoiesis by
	78	murine
	79	<a href="http://uniprot.org/uniprot/?query=P21183+or+Q01344" xmlns="http://www.w3.org/1999/xhtml">IL-5Ralpha</a> antisense oligonucleotide
	80	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:101]" content="In vitro and in vivo inhibition of interleukin (IL)-5-mediated eosinopoiesis by murine IL-5Ralpha antisense oligonucleotide" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.org/obo/owl/CHEBI#CHEBI_30430" rel="sioc:topic"/><a href="http://purl.org/obo/owl/REX#REX_0000218" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P21183" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q01344" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	81
	82	<pmid:11498591> dc:creator
	83	"C Pals",
	84	"I J Uings",
	85	"J A Raaijmakers",
	86	"J Armstrong",
	87	"J W Lammers",
	88	"L Koenderman",
	89	"M McKinnon",
	90	"N Geijsen",
	91	"P J Coffer" ;
	92	dc:date "Aug 2001" ;
	93	dc:publisher "Science (New York, N.Y.)" ;
	94	dc:title """
	95
	96	Cytokine-specific transcriptional regulation through an
	97	<a href="http://uniprot.org/uniprot/?query=P21183+or+Q01344" xmlns="http://www.w3.org/1999/xhtml">IL-5Ralpha</a> interacting
	98	protein
	99	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:108]" content="Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.uniprot.org/uniprot/P21183" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q01344" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	100
	101	<pmid:11606047> dc:creator
	102	"A Bègue",
	103	"A Capron",
	104	"C Pierrot",
	105	"C Szpirer",
	106	"J Khalife",
	107	"M Capron" ;
	108	dc:date "Oct 2001" ;
	109	dc:publisher "Biochemical and biophysical research communications" ;
	110	dc:title """
	111
	112	Cloning of the
	113	rat
	114	<a href="http://uniprot.org/uniprot/?query=P21183+or+Q01344" xmlns="http://www.w3.org/1999/xhtml">IL-5Ralpha</a> gene: analysis of
	115	5'- upstream region and expression by B cells
	116	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:115]" content="Cloning of the rat IL-5Ralpha gene: analysis of 5'- upstream region and expression by B cells" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.uniprot.org/uniprot/P21183" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q01344" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	117
	118	<pmid:12969637> dc:creator
	119	"D W Horohov",
	120	"E Vandergrifft",
	121	"F M Cunningham",
	122	"M F Sepulveda",
	123	"N T Goode",
	124	"S R Bailey" ;
	125	dc:date "Sep 2003" ;
	126	dc:publisher "Veterinary immunology and immunopathology" ;
	127	dc:title """
	128
	129	Cloning, expression and biological activity of equine interleukin (IL)-5. """ .
	130
	131	<pmid:15534922> dc:creator
	132	"Hatice Ertabaklar",
	133	"Nevin Turgay",
	134	"Sebnem Ustun",
	135	"Songul-Bayram Delibas" ;
	136	dc:date "Dec 2004" ;
	137	dc:publisher "World journal of gastroenterology : WJG" ;
	138	dc:title """
	139
	140	Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases. """ .
	141
	142	<pmid:16217591> dc:creator
	143	"Byoung Whui Choi",
	144	"Byung Lae Park",
	145	"Choon-Sik Park",
	146	"Hae-Sim Park",
	147	"Hyoung Doo Shin",
	148	"Hyun Sub Cheong",
	149	"Lyoung Hyo Kim",
	150	"Soo-Jong Hong",
	151	"Yoo Hyun Choi" ;
	152	dc:title """
	153
	154
	155	<a href="http://obofoundry.org/obo/REX:0000150" xmlns="http://www.w3.org/1999/xhtml">Association</a> analysis of interleukin 5 receptor
	156	<a href="http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30216" xmlns="http://www.w3.org/1999/xhtml">alpha</a> subunit (
	157	<a href="http://uniprot.org/uniprot/?query=Q01344" xmlns="http://www.w3.org/1999/xhtml">IL5RA</a>) polymorphisms and
	158	asthma
	159	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:144]" content="Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.org/obo/owl/REX#REX_0000150" rel="sioc:topic"/><a href="http://purl.org/obo/owl/CHEBI#CHEBI_30216" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q01344" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	160
	161	<pmid:17282969> dc:creator
	162	"Chia-Wei Hsieh",
	163	"Huei-Mei Huang",
	164	"Jaw-Ji Tsai",
	165	"Joung-Liang Lan",
	166	"Qiu Meng",
	167	"Ya-Wen Cheng" ;
	168	dc:date "Jan 2007" ;
	169	dc:publisher "Journal of the Formosan Medical Association = Taiwan yi zhi" ;
	170	dc:title """
	171
	172	Eosinophil
	173	<a href="http://www.ebi.ac.uk/ego/DisplayGoTerm?id=GO:0006915" xmlns="http://www.w3.org/1999/xhtml">apoptosis</a> induced by fungal immunomodulatory
	174	<a href="http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16670" xmlns="http://www.w3.org/1999/xhtml">peptide</a> -fve via reducing IL-5alpha receptor
	175	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:151]" content="Eosinophil apoptosis induced by fungal immunomodulatory peptide -fve via reducing IL-5alpha receptor" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.org/obo/owl/GO#GO_0006915" rel="sioc:topic"/><a href="http://purl.org/obo/owl/CHEBI#CHEBI_16670" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	176
	177	<pmid:18410960> dc:creator
	178	"Alexandra H Filipovich",
	179	"Amal H Assa'ad",
	180	"Bridget K Buckmeier",
	181	"Joyce M Villanueva",
	182	"Marc E Rothenberg",
	183	"Miguel L Stein",
	184	"Yoshiyuki Yamada" ;
	185	dc:date "Jun 2008" ;
	186	dc:publisher "The Journal of allergy and clinical immunology" ;
	187	dc:title """
	188
	189	Anti-
	190	<a href="http://uniprot.org/uniprot/?query=O02699+or+O08987+or+O77515+or+P04401+or+P05113+or+P46685+or+P48093+or+P52173+or+Q08125+or+Q28586+or+Q62575+or+Q95J76+or+Q9ESI9+or+Q9XT91" xmlns="http://www.w3.org/1999/xhtml">IL-5</a> (mepolizumab) therapy reduces
	191	<a href="http://www.ebi.ac.uk/ego/DisplayGoTerm?id=GO:0043307" xmlns="http://www.w3.org/1999/xhtml">eosinophil</a> ex vivo and increases
	192	<a href="http://uniprot.org/uniprot/?query=O02699+or+O08987+or+O77515+or+P04401+or+P05113+or+P46685+or+P48093+or+P52173+or+Q08125+or+Q28586+or+Q62575+or+Q95J76+or+Q9ESI9+or+Q9XT91" xmlns="http://www.w3.org/1999/xhtml">IL-5</a> and
	193	<a href="http://uniprot.org/uniprot/?query=O02699+or+O08987+or+O77515+or+P04401+or+P05113+or+P46685+or+P48093+or+P52173+or+Q08125+or+Q28586+or+Q62575+or+Q95J76+or+Q9ESI9+or+Q9XT91" xmlns="http://www.w3.org/1999/xhtml">IL-5</a> receptor levels
	194	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:163]" content="Anti- IL-5 (mepolizumab) therapy reduces eosinophil ex vivo and increases IL-5 and IL-5 receptor levels" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.uniprot.org/uniprot/O02699" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O08987" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O77515" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P04401" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P05113" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P46685" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P48093" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P52173" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q08125" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q28586" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q62575" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q95J76" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9ESI9" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9XT91" rel="sioc:topic"/><a href="http://purl.org/obo/owl/GO#GO_0043307" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O02699" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O08987" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O77515" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P04401" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P05113" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P46685" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P48093" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P52173" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q08125" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q28586" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q62575" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q95J76" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9ESI9" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9XT91" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O02699" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O08987" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/O77515" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P04401" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P05113" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P46685" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P48093" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P52173" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q08125" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q28586" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q62575" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q95J76" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9ESI9" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q9XT91" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	195
	196	<pmid:8630733> dc:creator
	197	"H Kanazawa",
	198	"H Sugaya",
	199	"J Miyazaki",
	200	"K Ikuta",
	201	"K Maki",
	202	"K Takatsu",
	203	"K Yoshimura",
	204	"M Takagi",
	205	"S Sunaga",
	206	"S Takaki",
	207	"T Kinashi",
	208	"T Yoshida" ;
	209	dc:date "May 1996" ;
	210	dc:publisher "Immunity" ;
	211	dc:title """
	212
	213	Defective B-1
	214	<a href="http://www.ebi.ac.uk/ego/DisplayGoTerm?id=GO:0048468" xmlns="http://www.w3.org/1999/xhtml">cell development</a> and impaired immunity against
	215	Angiostrongylus cantonensis in
	216	<a href="http://uniprot.org/uniprot/?query=P21183+or+Q01344" xmlns="http://www.w3.org/1999/xhtml">IL-5R alpha</a> -deficient
	217	mice
	218	<span class="atag" xmlns="http://www.w3.org/1999/xhtml"> <a<span about="[_:174]" content="Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha -deficient mice" property="sioc:content" typeof="sioc:Item" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#"><a href="http://purl.org/obo/owl/GO#GO_0048468" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/P21183" rel="sioc:topic"/><a href="http://purl.uniprot.org/uniprot/Q01344" rel="sioc:topic"/></span>></span>. """^^rdf:XMLLiteral .
	219
	220	[ a sioc:Item ;
	221	sioc:content "IL-5Ralpha ASOs were identified which selectively and specifically suppress the expression of messenger RNA and proteins of both the membrane and the soluble form of the receptor in constitutively IL-5R -expressing murine BCL-1 cells in vitro" ;
	222	sioc:topic
	223	<http://purl.org/obo/owl/CHEBI#CHEBI_33699>,
	224	<http://purl.org/obo/owl/CHEBI#CHEBI_36080>,
	225	<http://purl.org/obo/owl/GO#GO_0004914>,
	226	<http://purl.org/obo/owl/GO#GO_0016020>,
	227	<http://purl.uniprot.org/uniprot/P14133>,
	228	<http://purl.uniprot.org/uniprot/P21183>,
	229	<http://purl.uniprot.org/uniprot/P24792>,
	230	<http://purl.uniprot.org/uniprot/P37064>,
	231	<http://purl.uniprot.org/uniprot/Q01344>,
	232	<http://purl.uniprot.org/uniprot/Q40588>].
	233
	234	[ a sioc:Item ;
	235	sioc:content "Moreover, these IL-5Ralpha -specific ASOs were able to selectively inhibit the IL-5 -induced eosinopoesis from murine fetal liver and bone marrow cells in vitro, suggesting that these molecules may affect the development of IL-5 -mediated eosinophilia in vivo" ;
	236	sioc:topic
	237	<http://purl.org/obo/owl/CHEBI#CHEBI_25367>,
	238	<http://purl.org/obo/owl/GO#GO_0007275>,
	239	<http://purl.uniprot.org/uniprot/O02699>,
	240	<http://purl.uniprot.org/uniprot/O08987>,
	241	<http://purl.uniprot.org/uniprot/O77515>,
	242	<http://purl.uniprot.org/uniprot/P04401>,
	243	<http://purl.uniprot.org/uniprot/P05113>,
	244	<http://purl.uniprot.org/uniprot/P14133>,
	245	<http://purl.uniprot.org/uniprot/P21183>,
	246	<http://purl.uniprot.org/uniprot/P24792>,
	247	<http://purl.uniprot.org/uniprot/P37064>,
	248	<http://purl.uniprot.org/uniprot/P46685>,
	249	<http://purl.uniprot.org/uniprot/P48093>,
	250	<http://purl.uniprot.org/uniprot/P52173>,
	251	<http://purl.uniprot.org/uniprot/Q01344>,
	252	<http://purl.uniprot.org/uniprot/Q08125>,
	253	<http://purl.uniprot.org/uniprot/Q28586>,
	254	<http://purl.uniprot.org/uniprot/Q40588>,
	255	<http://purl.uniprot.org/uniprot/Q62575>,
	256	<http://purl.uniprot.org/uniprot/Q95J76>,
	257	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	258	<http://purl.uniprot.org/uniprot/Q9XT91>].
	259
	260	[ a sioc:Item ;
	261	sioc:content "Indeed, intravenous administration of IL-5Ralpha -specific ASOs not only suppressed the bone-marrow and blood eosinophilia in mice after short-term treatment with recombinant murine IL-5 but also inhibited the development of blood and tissue eosinophilia in a ragweed-induced allergic peritonitis model" ;
	262	sioc:topic
	263	<http://purl.org/obo/owl/GO#GO_0007275>,
	264	<http://purl.uniprot.org/uniprot/O02699>,
	265	<http://purl.uniprot.org/uniprot/O08987>,
	266	<http://purl.uniprot.org/uniprot/O77515>,
	267	<http://purl.uniprot.org/uniprot/P04401>,
	268	<http://purl.uniprot.org/uniprot/P05113>,
	269	<http://purl.uniprot.org/uniprot/P14133>,
	270	<http://purl.uniprot.org/uniprot/P21183>,
	271	<http://purl.uniprot.org/uniprot/P24792>,
	272	<http://purl.uniprot.org/uniprot/P37064>,
	273	<http://purl.uniprot.org/uniprot/P46685>,
	274	<http://purl.uniprot.org/uniprot/P48093>,
	275	<http://purl.uniprot.org/uniprot/P52173>,
	276	<http://purl.uniprot.org/uniprot/Q01344>,
	277	<http://purl.uniprot.org/uniprot/Q08125>,
	278	<http://purl.uniprot.org/uniprot/Q28586>,
	279	<http://purl.uniprot.org/uniprot/Q40588>,
	280	<http://purl.uniprot.org/uniprot/Q62575>,
	281	<http://purl.uniprot.org/uniprot/Q95J76>,
	282	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	283	<http://purl.uniprot.org/uniprot/Q9XT91>].
	284
	285	[ a sioc:Item ;
	286	sioc:content "Thus, blocking the expression of IL-5Ralpha on eosinophil using ASOs may have therapeutic benefits in eosinophilic diseases such as asthma" ;
	287	sioc:topic
	288	<http://purl.uniprot.org/uniprot/P14133>,
	289	<http://purl.uniprot.org/uniprot/P21183>,
	290	<http://purl.uniprot.org/uniprot/P24792>,
	291	<http://purl.uniprot.org/uniprot/P37064>,
	292	<http://purl.uniprot.org/uniprot/Q01344>,
	293	<http://purl.uniprot.org/uniprot/Q40588>].
	294
	295	[ a sioc:Item ;
	296	sioc:content "The interleukin 5 (IL-5) receptor consists of an IL-5 -specific alpha -subunit (IL-5Ralpha) and a signal-transducing beta -subunit (betac) shared with the IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors" ;
	297	sioc:topic
	298	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	299	<http://purl.uniprot.org/uniprot/O02699>,
	300	<http://purl.uniprot.org/uniprot/O08987>,
	301	<http://purl.uniprot.org/uniprot/O62757>,
	302	<http://purl.uniprot.org/uniprot/O77515>,
	303	<http://purl.uniprot.org/uniprot/P01586>,
	304	<http://purl.uniprot.org/uniprot/P01587>,
	305	<http://purl.uniprot.org/uniprot/P04141>,
	306	<http://purl.uniprot.org/uniprot/P04401>,
	307	<http://purl.uniprot.org/uniprot/P04823>,
	308	<http://purl.uniprot.org/uniprot/P05113>,
	309	<http://purl.uniprot.org/uniprot/P06740>,
	310	<http://purl.uniprot.org/uniprot/P08700>,
	311	<http://purl.uniprot.org/uniprot/P11052>,
	312	<http://purl.uniprot.org/uniprot/P21183>,
	313	<http://purl.uniprot.org/uniprot/P25140>,
	314	<http://purl.uniprot.org/uniprot/P28773>,
	315	<http://purl.uniprot.org/uniprot/P46685>,
	316	<http://purl.uniprot.org/uniprot/P48093>,
	317	<http://purl.uniprot.org/uniprot/P48749>,
	318	<http://purl.uniprot.org/uniprot/P48750>,
	319	<http://purl.uniprot.org/uniprot/P49875>,
	320	<http://purl.uniprot.org/uniprot/P51445>,
	321	<http://purl.uniprot.org/uniprot/P51748>,
	322	<http://purl.uniprot.org/uniprot/P52173>,
	323	<http://purl.uniprot.org/uniprot/Q01344>,
	324	<http://purl.uniprot.org/uniprot/Q06435>,
	325	<http://purl.uniprot.org/uniprot/Q08125>,
	326	<http://purl.uniprot.org/uniprot/Q0MUT8>,
	327	<http://purl.uniprot.org/uniprot/Q28334>,
	328	<http://purl.uniprot.org/uniprot/Q28586>,
	329	<http://purl.uniprot.org/uniprot/Q28809>,
	330	<http://purl.uniprot.org/uniprot/Q29118>,
	331	<http://purl.uniprot.org/uniprot/Q60481>,
	332	<http://purl.uniprot.org/uniprot/Q62575>,
	333	<http://purl.uniprot.org/uniprot/Q95J76>,
	334	<http://purl.uniprot.org/uniprot/Q9BDX4>,
	335	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	336	<http://purl.uniprot.org/uniprot/Q9XT91>].
	337
	338	[ a sioc:Item ;
	339	sioc:content "In this study, we sought to find a role for the cytoplasmic domain of IL-5Ralpha" ;
	340	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_30430>, <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	341
	342	[ a sioc:Item ;
	343	sioc:content "We show that syntenin, a protein containing PSD-95 /Discs large/zO-1 (PDZ) domains, associates with the cytoplasmic tail of the IL-5Ralpha" ;
	344	sioc:topic
	345	<http://purl.uniprot.org/uniprot/P03161>,
	346	<http://purl.uniprot.org/uniprot/P03610>,
	347	<http://purl.uniprot.org/uniprot/P03631>,
	348	<http://purl.uniprot.org/uniprot/P03632>,
	349	<http://purl.uniprot.org/uniprot/P07394>,
	350	<http://purl.uniprot.org/uniprot/P15966>,
	351	<http://purl.uniprot.org/uniprot/P21183>,
	352	<http://purl.uniprot.org/uniprot/P25243>,
	353	<http://purl.uniprot.org/uniprot/P25244>,
	354	<http://purl.uniprot.org/uniprot/P31016>,
	355	<http://purl.uniprot.org/uniprot/P35823>,
	356	<http://purl.uniprot.org/uniprot/P78352>,
	357	<http://purl.uniprot.org/uniprot/P98005>,
	358	<http://purl.uniprot.org/uniprot/Q01344>,
	359	<http://purl.uniprot.org/uniprot/Q62108>,
	360	<http://purl.uniprot.org/uniprot/Q6R005>].
	361
	362	[ a sioc:Item ;
	363	sioc:content "Syntenin was found to directly associate with the transcription factor Sox4" ;
	364	sioc:topic <http://purl.org/obo/owl/GO#GO_0006350>, <http://purl.uniprot.org/uniprot/Q06831>].
	365
	366	[ a sioc:Item ;
	367	sioc:content "Association of syntenin with IL-5Ralpha was required for IL-5 -mediated activation of Sox4" ;
	368	sioc:topic
	369	<http://purl.org/obo/owl/REX#REX_0000150>,
	370	<http://purl.org/obo/owl/REX#REX_0000221>,
	371	<http://purl.uniprot.org/uniprot/O02699>,
	372	<http://purl.uniprot.org/uniprot/O08987>,
	373	<http://purl.uniprot.org/uniprot/O77515>,
	374	<http://purl.uniprot.org/uniprot/P04401>,
	375	<http://purl.uniprot.org/uniprot/P05113>,
	376	<http://purl.uniprot.org/uniprot/P21183>,
	377	<http://purl.uniprot.org/uniprot/P46685>,
	378	<http://purl.uniprot.org/uniprot/P48093>,
	379	<http://purl.uniprot.org/uniprot/P52173>,
	380	<http://purl.uniprot.org/uniprot/Q01344>,
	381	<http://purl.uniprot.org/uniprot/Q06831>,
	382	<http://purl.uniprot.org/uniprot/Q08125>,
	383	<http://purl.uniprot.org/uniprot/Q28586>,
	384	<http://purl.uniprot.org/uniprot/Q62575>,
	385	<http://purl.uniprot.org/uniprot/Q95J76>,
	386	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	387	<http://purl.uniprot.org/uniprot/Q9XT91>].
	388
	389	[ a sioc:Item ;
	390	sioc:content "These studies identify a mechanism of transcriptional activation by cytokine-specific receptor subunits" ;
	391	sioc:topic <http://purl.org/obo/owl/REX#REX_0000221>].
	392
	393	[ a sioc:Item ;
	394	sioc:content "Although rats are widely used for the analysis of allergic reactions and parasitic infections where IL-5 is involved, nothing is currently known of the expression of IL-5 receptor in this species" ;
	395	sioc:topic
	396	<http://purl.uniprot.org/uniprot/O02699>,
	397	<http://purl.uniprot.org/uniprot/O08987>,
	398	<http://purl.uniprot.org/uniprot/O77515>,
	399	<http://purl.uniprot.org/uniprot/P04401>,
	400	<http://purl.uniprot.org/uniprot/P05113>,
	401	<http://purl.uniprot.org/uniprot/P46685>,
	402	<http://purl.uniprot.org/uniprot/P48093>,
	403	<http://purl.uniprot.org/uniprot/P52173>,
	404	<http://purl.uniprot.org/uniprot/Q08125>,
	405	<http://purl.uniprot.org/uniprot/Q28586>,
	406	<http://purl.uniprot.org/uniprot/Q62575>,
	407	<http://purl.uniprot.org/uniprot/Q95J76>,
	408	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	409	<http://purl.uniprot.org/uniprot/Q9XT91>].
	410
	411	[ a sioc:Item ;
	412	sioc:content "In this study, the cDNA sequence, genomic structure and the transcriptional regulation of the rat IL-5Ralpha were analyzed" ;
	413	sioc:topic
	414	<http://purl.org/obo/owl/CHEBI#CHEBI_30430>,
	415	<http://purl.org/obo/owl/FIX#FIX_0000300>,
	416	<http://purl.org/obo/owl/FIX#FIX_0000482>,
	417	<http://purl.uniprot.org/uniprot/P21183>,
	418	<http://purl.uniprot.org/uniprot/Q01344>].
	419
	420	[ a sioc:Item ;
	421	sioc:content "The rat IL-5Ralpha gene, which we localized to chromosome 4q34-q41, spans more than 25 kb and consists of 12 exons" ;
	422	sioc:topic <http://purl.org/obo/owl/GO#GO_0005694>, <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	423
	424	[ a sioc:Item ;
	425	sioc:content "Promoter activity was seen in different cell lines and analysis by deletion experiments allowed to identify two negative regulatory regions which did not differ when tested either with IL-5Ralpha -negative or positive cells" ;
	426	sioc:topic <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	427
	428	[ a sioc:Item ;
	429	sioc:content "Finally, the investigation of the expression of IL-5Ralpha showed that it is expressed in lung, spleen, liver, and purified rat B cells from normal rat" ;
	430	sioc:topic <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	431
	432	[ a sioc:Item ;
	433	sioc:content "This can provide an explanation for the role of rat IL-5 as B-cell growth factor and a relevant model in order to better understand the activity of IL-5 on human B cells" ;
	434	sioc:topic
	435	<http://purl.uniprot.org/uniprot/O02699>,
	436	<http://purl.uniprot.org/uniprot/O08987>,
	437	<http://purl.uniprot.org/uniprot/O77515>,
	438	<http://purl.uniprot.org/uniprot/P04401>,
	439	<http://purl.uniprot.org/uniprot/P05113>,
	440	<http://purl.uniprot.org/uniprot/P46685>,
	441	<http://purl.uniprot.org/uniprot/P48093>,
	442	<http://purl.uniprot.org/uniprot/P52173>,
	443	<http://purl.uniprot.org/uniprot/Q08125>,
	444	<http://purl.uniprot.org/uniprot/Q28586>,
	445	<http://purl.uniprot.org/uniprot/Q62575>,
	446	<http://purl.uniprot.org/uniprot/Q95J76>,
	447	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	448	<http://purl.uniprot.org/uniprot/Q9XT91>].
	449
	450	[ a sioc:Item ;
	451	sioc:content "The cytokine, interleukin (IL)-5 stimulates eosinophil differentiation, activation and survival and can prime these cells, increasing the response to other mediators" ;
	452	sioc:topic <http://purl.org/obo/owl/GO#GO_0030222>, <http://purl.org/obo/owl/REX#REX_0000221>].
	453
	454	[ a sioc:Item ;
	455	sioc:content "In view of its many effects on eosinophils, IL-5 has been implicated in the pathogenesis of allergic disease in" ;
	456	sioc:topic
	457	<http://purl.org/obo/owl/CHEBI#CHEBI_30430>,
	458	<http://purl.org/obo/owl/GO#GO_0009405>,
	459	<http://purl.uniprot.org/uniprot/O02699>,
	460	<http://purl.uniprot.org/uniprot/O08987>,
	461	<http://purl.uniprot.org/uniprot/O77515>,
	462	<http://purl.uniprot.org/uniprot/P04401>,
	463	<http://purl.uniprot.org/uniprot/P05113>,
	464	<http://purl.uniprot.org/uniprot/P46685>,
	465	<http://purl.uniprot.org/uniprot/P48093>,
	466	<http://purl.uniprot.org/uniprot/P52173>,
	467	<http://purl.uniprot.org/uniprot/Q08125>,
	468	<http://purl.uniprot.org/uniprot/Q28586>,
	469	<http://purl.uniprot.org/uniprot/Q62575>,
	470	<http://purl.uniprot.org/uniprot/Q95J76>,
	471	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	472	<http://purl.uniprot.org/uniprot/Q9XT91>].
	473
	474	[ a sioc:Item ;
	475	sioc:content "Here we report the cloning of equine IL-5 and expression of the recombinant protein by transfection of Chinese hamster ovary (CHO) cells" ;
	476	sioc:topic
	477	<http://purl.org/obo/owl/CHEBI#CHEBI_24089>,
	478	<http://purl.uniprot.org/uniprot/O02699>,
	479	<http://purl.uniprot.org/uniprot/O08987>,
	480	<http://purl.uniprot.org/uniprot/O77515>,
	481	<http://purl.uniprot.org/uniprot/P04401>,
	482	<http://purl.uniprot.org/uniprot/P05113>,
	483	<http://purl.uniprot.org/uniprot/P46685>,
	484	<http://purl.uniprot.org/uniprot/P48093>,
	485	<http://purl.uniprot.org/uniprot/P52173>,
	486	<http://purl.uniprot.org/uniprot/Q08125>,
	487	<http://purl.uniprot.org/uniprot/Q28586>,
	488	<http://purl.uniprot.org/uniprot/Q62575>,
	489	<http://purl.uniprot.org/uniprot/Q95J76>,
	490	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	491	<http://purl.uniprot.org/uniprot/Q9XT91>].
	492
	493	[ a sioc:Item ;
	494	sioc:content "The cloned cDNA sequence consisted of 405 nucleotides and encoded a protein of 135 amino acids" ;
	495	sioc:topic
	496	<http://purl.org/obo/owl/CHEBI#CHEBI_33709>,
	497	<http://purl.org/obo/owl/CHEBI#CHEBI_36976>,
	498	<http://purl.org/obo/owl/FIX#FIX_0000300>,
	499	<http://purl.uniprot.org/uniprot/P03161>,
	500	<http://purl.uniprot.org/uniprot/P03610>,
	501	<http://purl.uniprot.org/uniprot/P03631>,
	502	<http://purl.uniprot.org/uniprot/P03632>,
	503	<http://purl.uniprot.org/uniprot/P07394>,
	504	<http://purl.uniprot.org/uniprot/P15966>,
	505	<http://purl.uniprot.org/uniprot/P25243>,
	506	<http://purl.uniprot.org/uniprot/P25244>,
	507	<http://purl.uniprot.org/uniprot/P35823>,
	508	<http://purl.uniprot.org/uniprot/P98005>].
	509
	510	[ a sioc:Item ;
	511	sioc:content "Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha)" ;
	512	sioc:topic
	513	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	514	<http://purl.org/obo/owl/GO#GO_0005488>,
	515	<http://purl.uniprot.org/uniprot/O02699>,
	516	<http://purl.uniprot.org/uniprot/O08987>,
	517	<http://purl.uniprot.org/uniprot/O77515>,
	518	<http://purl.uniprot.org/uniprot/P04401>,
	519	<http://purl.uniprot.org/uniprot/P05113>,
	520	<http://purl.uniprot.org/uniprot/P21183>,
	521	<http://purl.uniprot.org/uniprot/P46685>,
	522	<http://purl.uniprot.org/uniprot/P48093>,
	523	<http://purl.uniprot.org/uniprot/P52173>,
	524	<http://purl.uniprot.org/uniprot/Q01344>,
	525	<http://purl.uniprot.org/uniprot/Q08125>,
	526	<http://purl.uniprot.org/uniprot/Q28586>,
	527	<http://purl.uniprot.org/uniprot/Q62575>,
	528	<http://purl.uniprot.org/uniprot/Q95J76>,
	529	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	530	<http://purl.uniprot.org/uniprot/Q9XT91>].
	531
	532	[ a sioc:Item ;
	533	sioc:content "There is >85% identity with feline, bovine, ovine, canine, and human IL-5 sequences at the nucleotide and protein level" ;
	534	sioc:topic
	535	<http://purl.uniprot.org/uniprot/O02699>,
	536	<http://purl.uniprot.org/uniprot/O08987>,
	537	<http://purl.uniprot.org/uniprot/O77515>,
	538	<http://purl.uniprot.org/uniprot/P04401>,
	539	<http://purl.uniprot.org/uniprot/P05113>,
	540	<http://purl.uniprot.org/uniprot/P46685>,
	541	<http://purl.uniprot.org/uniprot/P48093>,
	542	<http://purl.uniprot.org/uniprot/P52173>,
	543	<http://purl.uniprot.org/uniprot/Q08125>,
	544	<http://purl.uniprot.org/uniprot/Q28586>,
	545	<http://purl.uniprot.org/uniprot/Q62575>,
	546	<http://purl.uniprot.org/uniprot/Q95J76>,
	547	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	548	<http://purl.uniprot.org/uniprot/Q9XT91>].
	549
	550	[ a sioc:Item ;
	551	sioc:content "Supernatants containing equine IL-5 were also examined for biological activity" ;
	552	sioc:topic
	553	<http://purl.uniprot.org/uniprot/O02699>,
	554	<http://purl.uniprot.org/uniprot/O08987>,
	555	<http://purl.uniprot.org/uniprot/O77515>,
	556	<http://purl.uniprot.org/uniprot/P04401>,
	557	<http://purl.uniprot.org/uniprot/P05113>,
	558	<http://purl.uniprot.org/uniprot/P46685>,
	559	<http://purl.uniprot.org/uniprot/P48093>,
	560	<http://purl.uniprot.org/uniprot/P52173>,
	561	<http://purl.uniprot.org/uniprot/Q08125>,
	562	<http://purl.uniprot.org/uniprot/Q28586>,
	563	<http://purl.uniprot.org/uniprot/Q62575>,
	564	<http://purl.uniprot.org/uniprot/Q95J76>,
	565	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	566	<http://purl.uniprot.org/uniprot/Q9XT91>].
	567
	568	[ a sioc:Item ;
	569	sioc:content "CHO supernatant containing equine recombinant (eqr) IL-5, like the human ortholog (hrIL-5), induced concentration dependent equine eosinophil adherence to autologous serum-coated plastic (9.7+/-1.5% with a 1:100 dilution of eqrIL-5 and 9.1+/-1.6% adherence with 1 nM hrIL-5; n = 4)" ;
	570	sioc:topic
	571	<http://purl.org/obo/owl/CHEBI#CHEBI_24089>,
	572	<http://purl.org/obo/owl/CHEBI#CHEBI_30222>,
	573	<http://purl.uniprot.org/uniprot/O02699>,
	574	<http://purl.uniprot.org/uniprot/O08987>,
	575	<http://purl.uniprot.org/uniprot/O77515>,
	576	<http://purl.uniprot.org/uniprot/P04401>,
	577	<http://purl.uniprot.org/uniprot/P05113>,
	578	<http://purl.uniprot.org/uniprot/P46685>,
	579	<http://purl.uniprot.org/uniprot/P48093>,
	580	<http://purl.uniprot.org/uniprot/P52173>,
	581	<http://purl.uniprot.org/uniprot/Q08125>,
	582	<http://purl.uniprot.org/uniprot/Q28586>,
	583	<http://purl.uniprot.org/uniprot/Q62575>,
	584	<http://purl.uniprot.org/uniprot/Q95J76>,
	585	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	586	<http://purl.uniprot.org/uniprot/Q9XT91>].
	587
	588	[ a sioc:Item ;
	589	sioc:content "The eqr protein also caused concentration dependent superoxide production (11.9+/-2.4 nmol (reduced cytochrome (cyt) C)/10(6) cells at a 1:50 dilution, n = 4)" ;
	590	sioc:topic
	591	<http://purl.org/obo/owl/CHEBI#CHEBI_18421>,
	592	<http://purl.org/obo/owl/CHEBI#CHEBI_27594>,
	593	<http://purl.org/obo/owl/CHEBI#CHEBI_30222>,
	594	<http://purl.org/obo/owl/CHEBI#CHEBI_4056>,
	595	<http://purl.uniprot.org/uniprot/P95339>].
	596
	597	[ a sioc:Item ;
	598	sioc:content "In contrast, hrIL-5 only caused significant superoxide production when diluted in conditioned CHO medium, an effect that was inhibited by the anti- human mAb, TRFK5 (4.4+/-0.3 versus 0.3+/-0.4 nmol/10(6) cells for 0.5 nM hrIL-5 in the presence of the isotype matched IgG1 control (10 microM) and TRFK5 (10 microM), respectively)" ;
	599	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_18421>, <http://purl.org/obo/owl/CHEBI#CHEBI_24089>, <http://purl.org/obo/owl/CHEBI#CHEBI_30430>].
	600
	601	[ a sioc:Item ;
	602	sioc:content "TRFK5 also significantly inhibited hrIL-5 induced adherence at concentrations of 0.3 microg/ml and above but had no significant inhibitory effect on either superoxide or adherence caused by eqrIL-5" ;
	603	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_18421>].
	604
	605	[ a sioc:Item ;
	606	sioc:content "These results demonstrate that equine IL-5 expressed by CHO cells stimulates equine eosinophils, suggesting that this cytokine could play a role in eosinophil recruitment and activation in equine allergic disease" ;
	607	sioc:topic
	608	<http://purl.org/obo/owl/CHEBI#CHEBI_24089>,
	609	<http://purl.org/obo/owl/REX#REX_0000221>,
	610	<http://purl.uniprot.org/uniprot/O02699>,
	611	<http://purl.uniprot.org/uniprot/O08987>,
	612	<http://purl.uniprot.org/uniprot/O77515>,
	613	<http://purl.uniprot.org/uniprot/P04401>,
	614	<http://purl.uniprot.org/uniprot/P05113>,
	615	<http://purl.uniprot.org/uniprot/P46685>,
	616	<http://purl.uniprot.org/uniprot/P48093>,
	617	<http://purl.uniprot.org/uniprot/P52173>,
	618	<http://purl.uniprot.org/uniprot/Q08125>,
	619	<http://purl.uniprot.org/uniprot/Q28586>,
	620	<http://purl.uniprot.org/uniprot/Q62575>,
	621	<http://purl.uniprot.org/uniprot/Q95J76>,
	622	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	623	<http://purl.uniprot.org/uniprot/Q9XT91>].
	624
	625	[ a sioc:Item ;
	626	sioc:content "Eosinophilia occurs as a result of IL-5 synthesized from Th2 cells during allergic reactions" ;
	627	sioc:topic
	628	<http://purl.uniprot.org/uniprot/O02699>,
	629	<http://purl.uniprot.org/uniprot/O08987>,
	630	<http://purl.uniprot.org/uniprot/O77515>,
	631	<http://purl.uniprot.org/uniprot/P04401>,
	632	<http://purl.uniprot.org/uniprot/P05113>,
	633	<http://purl.uniprot.org/uniprot/P46685>,
	634	<http://purl.uniprot.org/uniprot/P48093>,
	635	<http://purl.uniprot.org/uniprot/P52173>,
	636	<http://purl.uniprot.org/uniprot/Q08125>,
	637	<http://purl.uniprot.org/uniprot/Q28586>,
	638	<http://purl.uniprot.org/uniprot/Q62575>,
	639	<http://purl.uniprot.org/uniprot/Q95J76>,
	640	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	641	<http://purl.uniprot.org/uniprot/Q9XT91>].
	642
	643	[ a sioc:Item ;
	644	sioc:content "IL-5 acts as a factor activating eosinophils" ;
	645	sioc:topic
	646	<http://purl.uniprot.org/uniprot/O02699>,
	647	<http://purl.uniprot.org/uniprot/O08987>,
	648	<http://purl.uniprot.org/uniprot/O77515>,
	649	<http://purl.uniprot.org/uniprot/P04401>,
	650	<http://purl.uniprot.org/uniprot/P05113>,
	651	<http://purl.uniprot.org/uniprot/P46685>,
	652	<http://purl.uniprot.org/uniprot/P48093>,
	653	<http://purl.uniprot.org/uniprot/P52173>,
	654	<http://purl.uniprot.org/uniprot/Q08125>,
	655	<http://purl.uniprot.org/uniprot/Q28586>,
	656	<http://purl.uniprot.org/uniprot/Q62575>,
	657	<http://purl.uniprot.org/uniprot/Q95J76>,
	658	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	659	<http://purl.uniprot.org/uniprot/Q9XT91>].
	660
	661	[ a sioc:Item ;
	662	sioc:content "The aim of this study was to compare the IL-5 cytokine measurements in serum samples and cell cultures" ;
	663	sioc:topic
	664	<http://purl.uniprot.org/uniprot/O02699>,
	665	<http://purl.uniprot.org/uniprot/O08987>,
	666	<http://purl.uniprot.org/uniprot/O77515>,
	667	<http://purl.uniprot.org/uniprot/P04401>,
	668	<http://purl.uniprot.org/uniprot/P05113>,
	669	<http://purl.uniprot.org/uniprot/P46685>,
	670	<http://purl.uniprot.org/uniprot/P48093>,
	671	<http://purl.uniprot.org/uniprot/P52173>,
	672	<http://purl.uniprot.org/uniprot/Q08125>,
	673	<http://purl.uniprot.org/uniprot/Q28586>,
	674	<http://purl.uniprot.org/uniprot/Q62575>,
	675	<http://purl.uniprot.org/uniprot/Q95J76>,
	676	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	677	<http://purl.uniprot.org/uniprot/Q9XT91>].
	678
	679	[ a sioc:Item ;
	680	sioc:content "They are located within the CD loop of the first fibronectin type III (FnIII)-like domain and the EF loop of the second FnIII-like domain" ;
	681	sioc:topic
	682	<http://purl.org/obo/owl/FIX#FIX_0000043>,
	683	<http://purl.uniprot.org/uniprot/P07589>,
	684	<http://purl.uniprot.org/uniprot/P11722>,
	685	<http://purl.uniprot.org/uniprot/Q28275>,
	686	<http://purl.uniprot.org/uniprot/Q28377>,
	687	<http://purl.uniprot.org/uniprot/Q28749>,
	688	<http://purl.uniprot.org/uniprot/Q91289>,
	689	<http://purl.uniprot.org/uniprot/Q91400>].
	690
	691	[ a sioc:Item ;
	692	sioc:content "IL-5 production in in vitro cell cultures prepared by using phytohemaglutinin (PHA) to stimulate peripheral blood mononuclear cells (PBMC) obtained from the blood samples taken from these patients were compared with the IL-5 level in serum" ;
	693	sioc:topic
	694	<http://purl.uniprot.org/uniprot/O02699>,
	695	<http://purl.uniprot.org/uniprot/O08987>,
	696	<http://purl.uniprot.org/uniprot/O77515>,
	697	<http://purl.uniprot.org/uniprot/P04401>,
	698	<http://purl.uniprot.org/uniprot/P05113>,
	699	<http://purl.uniprot.org/uniprot/P46685>,
	700	<http://purl.uniprot.org/uniprot/P48093>,
	701	<http://purl.uniprot.org/uniprot/P52173>,
	702	<http://purl.uniprot.org/uniprot/P80463>,
	703	<http://purl.uniprot.org/uniprot/Q08125>,
	704	<http://purl.uniprot.org/uniprot/Q28586>,
	705	<http://purl.uniprot.org/uniprot/Q62575>,
	706	<http://purl.uniprot.org/uniprot/Q95J76>,
	707	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	708	<http://purl.uniprot.org/uniprot/Q9XT91>].
	709
	710	[ a sioc:Item ;
	711	sioc:content "Furthermore, the IL-5 production in protozoon and helminth infections was also compared" ;
	712	sioc:topic
	713	<http://purl.uniprot.org/uniprot/O02699>,
	714	<http://purl.uniprot.org/uniprot/O08987>,
	715	<http://purl.uniprot.org/uniprot/O77515>,
	716	<http://purl.uniprot.org/uniprot/P04401>,
	717	<http://purl.uniprot.org/uniprot/P05113>,
	718	<http://purl.uniprot.org/uniprot/P46685>,
	719	<http://purl.uniprot.org/uniprot/P48093>,
	720	<http://purl.uniprot.org/uniprot/P52173>,
	721	<http://purl.uniprot.org/uniprot/Q08125>,
	722	<http://purl.uniprot.org/uniprot/Q28586>,
	723	<http://purl.uniprot.org/uniprot/Q62575>,
	724	<http://purl.uniprot.org/uniprot/Q95J76>,
	725	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	726	<http://purl.uniprot.org/uniprot/Q9XT91>].
	727
	728	[ a sioc:Item ;
	729	sioc:content "Absolute eosinophil values in 1 mm(3) of blood were calculated by means of peripheral smear in both groups within the scope of the study" ;
	730	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_24433>].
	731
	732	[ a sioc:Item ;
	733	sioc:content "As regards the values of the sera in both patients with parasite infection and controls, the IL-5 production was found to be higher in the cell culture supernatant (P <0.001 and P <0.05)" ;
	734	sioc:topic
	735	<http://purl.uniprot.org/uniprot/O02699>,
	736	<http://purl.uniprot.org/uniprot/O08987>,
	737	<http://purl.uniprot.org/uniprot/O77515>,
	738	<http://purl.uniprot.org/uniprot/P04401>,
	739	<http://purl.uniprot.org/uniprot/P05113>,
	740	<http://purl.uniprot.org/uniprot/P46685>,
	741	<http://purl.uniprot.org/uniprot/P48093>,
	742	<http://purl.uniprot.org/uniprot/P52173>,
	743	<http://purl.uniprot.org/uniprot/Q08125>,
	744	<http://purl.uniprot.org/uniprot/Q28586>,
	745	<http://purl.uniprot.org/uniprot/Q62575>,
	746	<http://purl.uniprot.org/uniprot/Q95J76>,
	747	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	748	<http://purl.uniprot.org/uniprot/Q9XT91>].
	749
	750	[ a sioc:Item ;
	751	sioc:content "When the IL-5 level of the patients with helminth parasites was compared with that of those with protozoon, it was determined that the IL-5 level in serum was more significant in the patients with protozoon than in those with helminth (P <0.05)" ;
	752	sioc:topic
	753	<http://purl.uniprot.org/uniprot/O02699>,
	754	<http://purl.uniprot.org/uniprot/O08987>,
	755	<http://purl.uniprot.org/uniprot/O77515>,
	756	<http://purl.uniprot.org/uniprot/P04401>,
	757	<http://purl.uniprot.org/uniprot/P05113>,
	758	<http://purl.uniprot.org/uniprot/P46685>,
	759	<http://purl.uniprot.org/uniprot/P48093>,
	760	<http://purl.uniprot.org/uniprot/P52173>,
	761	<http://purl.uniprot.org/uniprot/Q08125>,
	762	<http://purl.uniprot.org/uniprot/Q28586>,
	763	<http://purl.uniprot.org/uniprot/Q62575>,
	764	<http://purl.uniprot.org/uniprot/Q95J76>,
	765	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	766	<http://purl.uniprot.org/uniprot/Q9XT91>].
	767
	768	[ a sioc:Item ;
	769	sioc:content "In the study group, the patients were found to have parasites, the percentage of eosinophil was 7.0% compared to 6.5% in the control group" ;
	770	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_24433>, <http://purl.org/obo/owl/CHEBI#CHEBI_30430>].
	771
	772	[ a sioc:Item ;
	773	sioc:content "CONCLUSION: It was found that IL-5 cytokine levels in serum samples from the patients with helminth and protozoon displayed more measurable values as compared to the IL-5 levels after stimulation with mitogen" ;
	774	sioc:topic
	775	<http://purl.uniprot.org/uniprot/O02699>,
	776	<http://purl.uniprot.org/uniprot/O08987>,
	777	<http://purl.uniprot.org/uniprot/O77515>,
	778	<http://purl.uniprot.org/uniprot/P04401>,
	779	<http://purl.uniprot.org/uniprot/P05113>,
	780	<http://purl.uniprot.org/uniprot/P46685>,
	781	<http://purl.uniprot.org/uniprot/P48093>,
	782	<http://purl.uniprot.org/uniprot/P52173>,
	783	<http://purl.uniprot.org/uniprot/Q08125>,
	784	<http://purl.uniprot.org/uniprot/Q28586>,
	785	<http://purl.uniprot.org/uniprot/Q62575>,
	786	<http://purl.uniprot.org/uniprot/Q95J76>,
	787	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	788	<http://purl.uniprot.org/uniprot/Q9XT91>].
	789
	790	[ a sioc:Item ;
	791	sioc:content "It is concluded that IL-5 acts as a triggering factor in the toxiallergic complaints commonly seen in helminth and protozoon infections" ;
	792	sioc:topic
	793	<http://purl.uniprot.org/uniprot/O02699>,
	794	<http://purl.uniprot.org/uniprot/O08987>,
	795	<http://purl.uniprot.org/uniprot/O77515>,
	796	<http://purl.uniprot.org/uniprot/P04401>,
	797	<http://purl.uniprot.org/uniprot/P05113>,
	798	<http://purl.uniprot.org/uniprot/P46685>,
	799	<http://purl.uniprot.org/uniprot/P48093>,
	800	<http://purl.uniprot.org/uniprot/P52173>,
	801	<http://purl.uniprot.org/uniprot/Q08125>,
	802	<http://purl.uniprot.org/uniprot/Q28586>,
	803	<http://purl.uniprot.org/uniprot/Q62575>,
	804	<http://purl.uniprot.org/uniprot/Q95J76>,
	805	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	806	<http://purl.uniprot.org/uniprot/Q9XT91>].
	807
	808	[ a sioc:Item ;
	809	sioc:content "The alpha subunit of interleukin 5 receptor (IL5RA) on chromosome 3p26- p24 is known to regulate the development and function of eosinophils" ;
	810	sioc:topic
	811	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	812	<http://purl.org/obo/owl/GO#GO_0005694>,
	813	<http://purl.org/obo/owl/GO#GO_0007275>,
	814	<http://purl.uniprot.org/uniprot/O94811>,
	815	<http://purl.uniprot.org/uniprot/P06934>,
	816	<http://purl.uniprot.org/uniprot/P07749>,
	817	<http://purl.uniprot.org/uniprot/P21926>,
	818	<http://purl.uniprot.org/uniprot/P24078>,
	819	<http://purl.uniprot.org/uniprot/P25880>,
	820	<http://purl.uniprot.org/uniprot/P25881>,
	821	<http://purl.uniprot.org/uniprot/P25882>,
	822	<http://purl.uniprot.org/uniprot/P25884>,
	823	<http://purl.uniprot.org/uniprot/P25989>,
	824	<http://purl.uniprot.org/uniprot/P26668>,
	825	<http://purl.uniprot.org/uniprot/P27500>,
	826	<http://purl.uniprot.org/uniprot/P27920>,
	827	<http://purl.uniprot.org/uniprot/P29833>,
	828	<http://purl.uniprot.org/uniprot/P29996>,
	829	<http://purl.uniprot.org/uniprot/P29997>,
	830	<http://purl.uniprot.org/uniprot/P41678>,
	831	<http://purl.uniprot.org/uniprot/P69618>,
	832	<http://purl.uniprot.org/uniprot/P69619>,
	833	<http://purl.uniprot.org/uniprot/Q01344>,
	834	<http://purl.uniprot.org/uniprot/Q62397>,
	835	<http://purl.uniprot.org/uniprot/Q81835>,
	836	<http://purl.uniprot.org/uniprot/Q81842>,
	837	<http://purl.uniprot.org/uniprot/Q8NNH6>,
	838	<http://purl.uniprot.org/uniprot/Q91DH7>,
	839	<http://purl.uniprot.org/uniprot/Q91DH8>,
	840	<http://purl.uniprot.org/uniprot/Q91DH9>,
	841	<http://purl.uniprot.org/uniprot/Q91QT2>,
	842	<http://purl.uniprot.org/uniprot/Q9CQM0>,
	843	<http://purl.uniprot.org/uniprot/Q9E925>,
	844	<http://purl.uniprot.org/uniprot/Q9T1S4>,
	845	<http://purl.uniprot.org/uniprot/Q9ZV04>].
	846
	847	[ a sioc:Item ;
	848	sioc:content "In an effort to discover additional polymorphism(s) in genes whose variant(s) have been implicated in asthma, we investigated the genetic polymorphisms in IL5RA to evaluate the gene as a potential candidate for a host genetic study of asthma" ;
	849	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_30430>, <http://purl.org/obo/owl/GO#GO_0018995>, <http://purl.uniprot.org/uniprot/Q01344>].
	850
	851	[ a sioc:Item ;
	852	sioc:content "The first binding site was identified by exploiting the different abilities of human IL-5Ralpha (hIL-5Ralpha) and mouse IL-5Ralpha (mIL-5Ralpha) to bind hIL-5" ;
	853	sioc:topic <http://purl.org/obo/owl/GO#GO_0005488>, <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	854
	855	[ a sioc:Item ;
	856	sioc:content "By direct DNA sequencing in 24 individuals, we identified 22 sequence variants within exons and flanking regions including a 1.5-kb promoter region of IL5RA; 10 common polymorphic sites were selected for genotyping in our asthma cohort (n = 587)" ;
	857	sioc:topic
	858	<http://purl.org/obo/owl/CHEBI#CHEBI_30222>,
	859	<http://purl.org/obo/owl/FIX#FIX_0000300>,
	860	<http://purl.org/obo/owl/FIX#FIX_0000873>,
	861	<http://purl.uniprot.org/uniprot/Q01344>].
	862
	863	[ a sioc:Item ;
	864	sioc:content "Statistical analysis revealed that one promoter SNP, c.-5993A > G, and one ins/ del polymorphism in intron 3, c.-480_482insdelGTT, showed significant association with the risk of asthma development" ;
	865	sioc:topic <http://purl.org/obo/owl/GO#GO_0007275>, <http://purl.org/obo/owl/REX#REX_0000150>].
	866
	867	[ a sioc:Item ;
	868	sioc:content "Our findings suggest that polymorphisms in IL5RA might be among the genetic risk factors for asthma development, especially in atopic populations" ;
	869	sioc:topic <http://purl.org/obo/owl/GO#GO_0007275>, <http://purl.uniprot.org/uniprot/Q01344>].
	870
	871	[ a sioc:Item ;
	872	sioc:content "IL5RA variant/haplotype information identified in this study will provide valuable information for strategies for the control of asthma" ;
	873	sioc:topic <http://purl.uniprot.org/uniprot/Q01344>].
	874
	875	[ a sioc:Item ;
	876	sioc:content "BACKGROUND/PURPOSE: Eosinophils are important effector cells in the pathogenesis of allergic bronchial asthma" ;
	877	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_35224>, <http://purl.org/obo/owl/GO#GO_0009405>].
	878
	879	[ a sioc:Item ;
	880	sioc:content "Enhancement of eosinophil apoptosis has been considered to have therapeutic effect on allergic disease" ;
	881	sioc:topic <http://purl.org/obo/owl/GO#GO_0006915>].
	882
	883	[ a sioc:Item ;
	884	sioc:content "Fungal immunomodulatory peptide (FIP)-fve has been reported to possess immunoprophylactic activities for allergic diseases" ;
	885	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_16670>, <http://purl.uniprot.org/uniprot/Q15853>].
	886
	887	[ a sioc:Item ;
	888	sioc:content "The purpose of this study was to investigate the modulation of FIP -fve on human eosinophil survival derived from allergic asthmatic patients" ;
	889	sioc:topic <http://purl.uniprot.org/uniprot/Q15853>].
	890
	891	[ a sioc:Item ;
	892	sioc:content "Apoptosis was assessed by annexin V and propidium iodide" ;
	893	sioc:topic
	894	<http://purl.org/obo/owl/GO#GO_0006915>,
	895	<http://purl.uniprot.org/uniprot/P08758>,
	896	<http://purl.uniprot.org/uniprot/P14668>,
	897	<http://purl.uniprot.org/uniprot/P17153>,
	898	<http://purl.uniprot.org/uniprot/P48036>,
	899	<http://purl.uniprot.org/uniprot/P70075>,
	900	<http://purl.uniprot.org/uniprot/P81287>,
	901	<http://purl.uniprot.org/uniprot/Q4R4H7>,
	902	<http://purl.uniprot.org/uniprot/Q5R1W0>].
	903
	904	[ a sioc:Item ;
	905	sioc:content "The apoptotic signal protein, CD95 and IL-5 receptor expression were assessed by Western blot and flow cytometric analysis" ;
	906	sioc:topic
	907	<http://purl.uniprot.org/uniprot/O02699>,
	908	<http://purl.uniprot.org/uniprot/O08987>,
	909	<http://purl.uniprot.org/uniprot/O77515>,
	910	<http://purl.uniprot.org/uniprot/P04401>,
	911	<http://purl.uniprot.org/uniprot/P05113>,
	912	<http://purl.uniprot.org/uniprot/P46685>,
	913	<http://purl.uniprot.org/uniprot/P48093>,
	914	<http://purl.uniprot.org/uniprot/P52173>,
	915	<http://purl.uniprot.org/uniprot/Q08125>,
	916	<http://purl.uniprot.org/uniprot/Q28586>,
	917	<http://purl.uniprot.org/uniprot/Q62575>,
	918	<http://purl.uniprot.org/uniprot/Q95J76>,
	919	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	920	<http://purl.uniprot.org/uniprot/Q9XT91>].
	921
	922	[ a sioc:Item ;
	923	sioc:content "Here we show that ovine IL-5 (oIL-5) has the ability to activate the hIL-5Ralpha but not the mIL-5Ralpha" ;
	924	sioc:topic
	925	<http://purl.uniprot.org/uniprot/O02699>,
	926	<http://purl.uniprot.org/uniprot/O08987>,
	927	<http://purl.uniprot.org/uniprot/O77515>,
	928	<http://purl.uniprot.org/uniprot/P04401>,
	929	<http://purl.uniprot.org/uniprot/P05113>,
	930	<http://purl.uniprot.org/uniprot/P46685>,
	931	<http://purl.uniprot.org/uniprot/P48093>,
	932	<http://purl.uniprot.org/uniprot/P52173>,
	933	<http://purl.uniprot.org/uniprot/Q08125>,
	934	<http://purl.uniprot.org/uniprot/Q28586>,
	935	<http://purl.uniprot.org/uniprot/Q62575>,
	936	<http://purl.uniprot.org/uniprot/Q95J76>,
	937	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	938	<http://purl.uniprot.org/uniprot/Q9XT91>].
	939
	940	[ a sioc:Item ;
	941	sioc:content "RESULTS: When the eosinophils were treated with FIP -fve in the presence of IL-5, IL-5 -enhanced eosinophil survival diminished" ;
	942	sioc:topic
	943	<http://purl.uniprot.org/uniprot/O02699>,
	944	<http://purl.uniprot.org/uniprot/O08987>,
	945	<http://purl.uniprot.org/uniprot/O77515>,
	946	<http://purl.uniprot.org/uniprot/P04401>,
	947	<http://purl.uniprot.org/uniprot/P05113>,
	948	<http://purl.uniprot.org/uniprot/P46685>,
	949	<http://purl.uniprot.org/uniprot/P48093>,
	950	<http://purl.uniprot.org/uniprot/P52173>,
	951	<http://purl.uniprot.org/uniprot/Q08125>,
	952	<http://purl.uniprot.org/uniprot/Q15853>,
	953	<http://purl.uniprot.org/uniprot/Q28586>,
	954	<http://purl.uniprot.org/uniprot/Q62575>,
	955	<http://purl.uniprot.org/uniprot/Q95J76>,
	956	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	957	<http://purl.uniprot.org/uniprot/Q9XT91>].
	958
	959	[ a sioc:Item ;
	960	sioc:content "FIP -fve could reduce IL-5 -mediated survival of eosinophils and decrease IL-5Ralpha expression" ;
	961	sioc:topic
	962	<http://purl.uniprot.org/uniprot/O02699>,
	963	<http://purl.uniprot.org/uniprot/O08987>,
	964	<http://purl.uniprot.org/uniprot/O77515>,
	965	<http://purl.uniprot.org/uniprot/P04401>,
	966	<http://purl.uniprot.org/uniprot/P05113>,
	967	<http://purl.uniprot.org/uniprot/P21183>,
	968	<http://purl.uniprot.org/uniprot/P46685>,
	969	<http://purl.uniprot.org/uniprot/P48093>,
	970	<http://purl.uniprot.org/uniprot/P52173>,
	971	<http://purl.uniprot.org/uniprot/Q01344>,
	972	<http://purl.uniprot.org/uniprot/Q08125>,
	973	<http://purl.uniprot.org/uniprot/Q15853>,
	974	<http://purl.uniprot.org/uniprot/Q28586>,
	975	<http://purl.uniprot.org/uniprot/Q62575>,
	976	<http://purl.uniprot.org/uniprot/Q95J76>,
	977	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	978	<http://purl.uniprot.org/uniprot/Q9XT91>].
	979
	980	[ a sioc:Item ;
	981	sioc:content "In the presence of FIP -fve, CD95 expression was upregulated and Bcl-xL and pro -caspase 3 expression were downregulated in cultured eosinophils" ;
	982	sioc:topic
	983	<http://purl.org/obo/owl/CHEBI#CHEBI_30017>,
	984	<http://purl.org/obo/owl/CHEBI#CHEBI_30430>,
	985	<http://purl.org/obo/owl/CHEBI#CHEBI_32865>,
	986	<http://purl.org/obo/owl/CHEBI#CHEBI_32866>,
	987	<http://purl.uniprot.org/uniprot/Q15853>].
	988
	989	[ a sioc:Item ;
	990	sioc:content "CONCLUSION: The results suggest that FIP -fve can inhibit IL-5 -mediated survival of eosinophils through the modulation of cytokine receptor expression and apoptotic signal protein production" ;
	991	sioc:topic
	992	<http://purl.uniprot.org/uniprot/O02699>,
	993	<http://purl.uniprot.org/uniprot/O08987>,
	994	<http://purl.uniprot.org/uniprot/O77515>,
	995	<http://purl.uniprot.org/uniprot/P04401>,
	996	<http://purl.uniprot.org/uniprot/P05113>,
	997	<http://purl.uniprot.org/uniprot/P46685>,
	998	<http://purl.uniprot.org/uniprot/P48093>,
	999	<http://purl.uniprot.org/uniprot/P52173>,
	1000	<http://purl.uniprot.org/uniprot/Q08125>,
	1001	<http://purl.uniprot.org/uniprot/Q15853>,
	1002	<http://purl.uniprot.org/uniprot/Q28586>,
	1003	<http://purl.uniprot.org/uniprot/Q62575>,
	1004	<http://purl.uniprot.org/uniprot/Q95J76>,
	1005	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1006	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1007
	1008	[ a sioc:Item ;
	1009	sioc:content "The modulatory effect of FIP -fve on eosinophil apoptosis in vitro indicates that it may have some therapeutic effect on eosinophil-related allergic inflammation in vivo" ;
	1010	sioc:topic <http://purl.org/obo/owl/GO#GO_0006915>, <http://purl.uniprot.org/uniprot/Q15853>].
	1011
	1012	[ a sioc:Item ;
	1013	sioc:content "BACKGROUND: Anti- IL-5 might be a useful therapeutic agent for eosinophilic disorders, yet its immunologic consequences have not been well characterized" ;
	1014	sioc:topic
	1015	<http://purl.uniprot.org/uniprot/O02699>,
	1016	<http://purl.uniprot.org/uniprot/O08987>,
	1017	<http://purl.uniprot.org/uniprot/O77515>,
	1018	<http://purl.uniprot.org/uniprot/P04401>,
	1019	<http://purl.uniprot.org/uniprot/P05113>,
	1020	<http://purl.uniprot.org/uniprot/P46685>,
	1021	<http://purl.uniprot.org/uniprot/P48093>,
	1022	<http://purl.uniprot.org/uniprot/P52173>,
	1023	<http://purl.uniprot.org/uniprot/Q08125>,
	1024	<http://purl.uniprot.org/uniprot/Q28586>,
	1025	<http://purl.uniprot.org/uniprot/Q62575>,
	1026	<http://purl.uniprot.org/uniprot/Q95J76>,
	1027	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1028	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1029
	1030	[ a sioc:Item ;
	1031	sioc:content "OBJECTIVE: We sought to characterize the hematologic and immunologic effects of anti- IL-5 in human subjects" ;
	1032	sioc:topic
	1033	<http://purl.uniprot.org/uniprot/O02699>,
	1034	<http://purl.uniprot.org/uniprot/O08987>,
	1035	<http://purl.uniprot.org/uniprot/O77515>,
	1036	<http://purl.uniprot.org/uniprot/P04401>,
	1037	<http://purl.uniprot.org/uniprot/P05113>,
	1038	<http://purl.uniprot.org/uniprot/P46685>,
	1039	<http://purl.uniprot.org/uniprot/P48093>,
	1040	<http://purl.uniprot.org/uniprot/P52173>,
	1041	<http://purl.uniprot.org/uniprot/Q08125>,
	1042	<http://purl.uniprot.org/uniprot/Q28586>,
	1043	<http://purl.uniprot.org/uniprot/Q62575>,
	1044	<http://purl.uniprot.org/uniprot/Q95J76>,
	1045	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1046	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1047
	1048	[ a sioc:Item ;
	1049	sioc:content "Samples with increased IL-5 levels after therapy were analyzed by using size exclusion filtration" ;
	1050	sioc:topic
	1051	<http://purl.org/obo/owl/FIX#FIX_0000496>,
	1052	<http://purl.uniprot.org/uniprot/O02699>,
	1053	<http://purl.uniprot.org/uniprot/O08987>,
	1054	<http://purl.uniprot.org/uniprot/O77515>,
	1055	<http://purl.uniprot.org/uniprot/P04401>,
	1056	<http://purl.uniprot.org/uniprot/P05113>,
	1057	<http://purl.uniprot.org/uniprot/P46685>,
	1058	<http://purl.uniprot.org/uniprot/P48093>,
	1059	<http://purl.uniprot.org/uniprot/P52173>,
	1060	<http://purl.uniprot.org/uniprot/Q08125>,
	1061	<http://purl.uniprot.org/uniprot/Q28586>,
	1062	<http://purl.uniprot.org/uniprot/Q62575>,
	1063	<http://purl.uniprot.org/uniprot/Q95J76>,
	1064	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1065	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1066
	1067	[ a sioc:Item ;
	1068	sioc:content "Immunoreactive IL-5 fraction and plasma samples were subsequently precipitated with saturating concentrations of protein A /G" ;
	1069	sioc:topic
	1070	<http://purl.uniprot.org/uniprot/O02699>,
	1071	<http://purl.uniprot.org/uniprot/O08987>,
	1072	<http://purl.uniprot.org/uniprot/O77515>,
	1073	<http://purl.uniprot.org/uniprot/P02810>,
	1074	<http://purl.uniprot.org/uniprot/P03064>,
	1075	<http://purl.uniprot.org/uniprot/P04401>,
	1076	<http://purl.uniprot.org/uniprot/P05113>,
	1077	<http://purl.uniprot.org/uniprot/P07602>,
	1078	<http://purl.uniprot.org/uniprot/P18164>,
	1079	<http://purl.uniprot.org/uniprot/P26779>,
	1080	<http://purl.uniprot.org/uniprot/P46685>,
	1081	<http://purl.uniprot.org/uniprot/P48093>,
	1082	<http://purl.uniprot.org/uniprot/P52173>,
	1083	<http://purl.uniprot.org/uniprot/Q08125>,
	1084	<http://purl.uniprot.org/uniprot/Q28586>,
	1085	<http://purl.uniprot.org/uniprot/Q62575>,
	1086	<http://purl.uniprot.org/uniprot/Q66929>,
	1087	<http://purl.uniprot.org/uniprot/Q95J76>,
	1088	<http://purl.uniprot.org/uniprot/Q96631>,
	1089	<http://purl.uniprot.org/uniprot/Q992J0>,
	1090	<http://purl.uniprot.org/uniprot/Q993M1>,
	1091	<http://purl.uniprot.org/uniprot/Q9DIC5>,
	1092	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1093	<http://purl.uniprot.org/uniprot/Q9IMM4>,
	1094	<http://purl.uniprot.org/uniprot/Q9J7Z2>,
	1095	<http://purl.uniprot.org/uniprot/Q9QAZ8>,
	1096	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1097
	1098	[ a sioc:Item ;
	1099	sioc:content "RESULTS: Twenty-three patients responded to anti- IL-5 therapy with a decrease in blood eosinophil counts and a reduced percentage of CCR3 (+) cells by 20- and 13- fold, respectively (P < .0001)" ;
	1100	sioc:topic
	1101	<http://purl.uniprot.org/uniprot/O02699>,
	1102	<http://purl.uniprot.org/uniprot/O08987>,
	1103	<http://purl.uniprot.org/uniprot/O54814>,
	1104	<http://purl.uniprot.org/uniprot/O77515>,
	1105	<http://purl.uniprot.org/uniprot/P04401>,
	1106	<http://purl.uniprot.org/uniprot/P05113>,
	1107	<http://purl.uniprot.org/uniprot/P46685>,
	1108	<http://purl.uniprot.org/uniprot/P48093>,
	1109	<http://purl.uniprot.org/uniprot/P51677>,
	1110	<http://purl.uniprot.org/uniprot/P51678>,
	1111	<http://purl.uniprot.org/uniprot/P52173>,
	1112	<http://purl.uniprot.org/uniprot/P56483>,
	1113	<http://purl.uniprot.org/uniprot/P56492>,
	1114	<http://purl.uniprot.org/uniprot/Q08125>,
	1115	<http://purl.uniprot.org/uniprot/Q28586>,
	1116	<http://purl.uniprot.org/uniprot/Q62575>,
	1117	<http://purl.uniprot.org/uniprot/Q64H34>,
	1118	<http://purl.uniprot.org/uniprot/Q95J76>,
	1119	<http://purl.uniprot.org/uniprot/Q9BDS8>,
	1120	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1121	<http://purl.uniprot.org/uniprot/Q9XT91>,
	1122	<http://purl.uniprot.org/uniprot/Q9Z2I3>].
	1123
	1124	[ a sioc:Item ;
	1125	sioc:content "These results show that regions of the third FnIII domain of IL-5Ralpha are involved in binding, in addition to the regions in domains one and two of the IL-5Ralpha that were identified in an earlier study" ;
	1126	sioc:topic
	1127	<http://purl.org/obo/owl/GO#GO_0005488>,
	1128	<http://purl.org/obo/owl/REX#REX_0000089>,
	1129	<http://purl.uniprot.org/uniprot/P21183>,
	1130	<http://purl.uniprot.org/uniprot/Q01344>].
	1131
	1132	[ a sioc:Item ;
	1133	sioc:content "Responsiveness was not related to the levels of baseline plasma IL-5 or the presence of FIP1L1 - PDGFRA fusion gene" ;
	1134	sioc:topic
	1135	<http://purl.uniprot.org/uniprot/O02699>,
	1136	<http://purl.uniprot.org/uniprot/O08987>,
	1137	<http://purl.uniprot.org/uniprot/O77515>,
	1138	<http://purl.uniprot.org/uniprot/P04401>,
	1139	<http://purl.uniprot.org/uniprot/P05113>,
	1140	<http://purl.uniprot.org/uniprot/P16234>,
	1141	<http://purl.uniprot.org/uniprot/P46685>,
	1142	<http://purl.uniprot.org/uniprot/P48093>,
	1143	<http://purl.uniprot.org/uniprot/P52173>,
	1144	<http://purl.uniprot.org/uniprot/Q08125>,
	1145	<http://purl.uniprot.org/uniprot/Q28586>,
	1146	<http://purl.uniprot.org/uniprot/Q5RAA7>,
	1147	<http://purl.uniprot.org/uniprot/Q62575>,
	1148	<http://purl.uniprot.org/uniprot/Q6UN15>,
	1149	<http://purl.uniprot.org/uniprot/Q8AXC7>,
	1150	<http://purl.uniprot.org/uniprot/Q95J76>,
	1151	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1152	<http://purl.uniprot.org/uniprot/Q9PUF6>,
	1153	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1154
	1155	[ a sioc:Item ;
	1156	sioc:content "Therapy was associated with a large increase in blood IL-5 levels, likely because of a circulating IL-5 /mepolizumab complex precipitated with protein A /G, a significant increase in eosinophil IL-5 receptor alpha expression, and increased percentage of CD4 (+) and CD8(+) cells producing intracellular IL-5 (P < .05)" ;
	1157	sioc:topic
	1158	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	1159	<http://purl.org/obo/owl/GO#GO_0005622>,
	1160	<http://purl.uniprot.org/uniprot/O02699>,
	1161	<http://purl.uniprot.org/uniprot/O08987>,
	1162	<http://purl.uniprot.org/uniprot/O77515>,
	1163	<http://purl.uniprot.org/uniprot/P01730>,
	1164	<http://purl.uniprot.org/uniprot/P02810>,
	1165	<http://purl.uniprot.org/uniprot/P03064>,
	1166	<http://purl.uniprot.org/uniprot/P04401>,
	1167	<http://purl.uniprot.org/uniprot/P05113>,
	1168	<http://purl.uniprot.org/uniprot/P05542>,
	1169	<http://purl.uniprot.org/uniprot/P07602>,
	1170	<http://purl.uniprot.org/uniprot/P16003>,
	1171	<http://purl.uniprot.org/uniprot/P16004>,
	1172	<http://purl.uniprot.org/uniprot/P18164>,
	1173	<http://purl.uniprot.org/uniprot/P26779>,
	1174	<http://purl.uniprot.org/uniprot/P33705>,
	1175	<http://purl.uniprot.org/uniprot/P46630>,
	1176	<http://purl.uniprot.org/uniprot/P46685>,
	1177	<http://purl.uniprot.org/uniprot/P48093>,
	1178	<http://purl.uniprot.org/uniprot/P52173>,
	1179	<http://purl.uniprot.org/uniprot/P79184>,
	1180	<http://purl.uniprot.org/uniprot/P79185>,
	1181	<http://purl.uniprot.org/uniprot/Q08125>,
	1182	<http://purl.uniprot.org/uniprot/Q08336>,
	1183	<http://purl.uniprot.org/uniprot/Q08338>,
	1184	<http://purl.uniprot.org/uniprot/Q08339>,
	1185	<http://purl.uniprot.org/uniprot/Q08340>,
	1186	<http://purl.uniprot.org/uniprot/Q28586>,
	1187	<http://purl.uniprot.org/uniprot/Q29037>,
	1188	<http://purl.uniprot.org/uniprot/Q62575>,
	1189	<http://purl.uniprot.org/uniprot/Q66929>,
	1190	<http://purl.uniprot.org/uniprot/Q95J76>,
	1191	<http://purl.uniprot.org/uniprot/Q96631>,
	1192	<http://purl.uniprot.org/uniprot/Q992J0>,
	1193	<http://purl.uniprot.org/uniprot/Q993M1>,
	1194	<http://purl.uniprot.org/uniprot/Q9DIC5>,
	1195	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1196	<http://purl.uniprot.org/uniprot/Q9IMM4>,
	1197	<http://purl.uniprot.org/uniprot/Q9J7Z2>,
	1198	<http://purl.uniprot.org/uniprot/Q9QAZ8>,
	1199	<http://purl.uniprot.org/uniprot/Q9XS78>,
	1200	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1201
	1202	[ a sioc:Item ;
	1203	sioc:content "Additionally, anti- IL-5 therapy decreased eotaxin-stimulated eosinophil shape change ex vivo" ;
	1204	sioc:topic
	1205	<http://purl.org/obo/owl/FIX#FIX_0000498>,
	1206	<http://purl.uniprot.org/uniprot/O02699>,
	1207	<http://purl.uniprot.org/uniprot/O08987>,
	1208	<http://purl.uniprot.org/uniprot/O77515>,
	1209	<http://purl.uniprot.org/uniprot/P04401>,
	1210	<http://purl.uniprot.org/uniprot/P05113>,
	1211	<http://purl.uniprot.org/uniprot/P46685>,
	1212	<http://purl.uniprot.org/uniprot/P48093>,
	1213	<http://purl.uniprot.org/uniprot/P52173>,
	1214	<http://purl.uniprot.org/uniprot/Q08125>,
	1215	<http://purl.uniprot.org/uniprot/Q28586>,
	1216	<http://purl.uniprot.org/uniprot/Q62575>,
	1217	<http://purl.uniprot.org/uniprot/Q95J76>,
	1218	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1219	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1220
	1221	[ a sioc:Item ;
	1222	sioc:content "CONCLUSIONS: Anti- IL-5 therapy induces a dramatic and sustained decrease in blood eosinophilia (including CCR3 (+) cells), decreased eosinophil , and increased circulating levels of IL-5 in a variety of eosinophilic disorders" ;
	1223	sioc:topic
	1224	<http://purl.org/obo/owl/GO#GO_0043307>,
	1225	<http://purl.uniprot.org/uniprot/O02699>,
	1226	<http://purl.uniprot.org/uniprot/O08987>,
	1227	<http://purl.uniprot.org/uniprot/O54814>,
	1228	<http://purl.uniprot.org/uniprot/O77515>,
	1229	<http://purl.uniprot.org/uniprot/P04401>,
	1230	<http://purl.uniprot.org/uniprot/P05113>,
	1231	<http://purl.uniprot.org/uniprot/P46685>,
	1232	<http://purl.uniprot.org/uniprot/P48093>,
	1233	<http://purl.uniprot.org/uniprot/P51677>,
	1234	<http://purl.uniprot.org/uniprot/P51678>,
	1235	<http://purl.uniprot.org/uniprot/P52173>,
	1236	<http://purl.uniprot.org/uniprot/P56483>,
	1237	<http://purl.uniprot.org/uniprot/P56492>,
	1238	<http://purl.uniprot.org/uniprot/Q08125>,
	1239	<http://purl.uniprot.org/uniprot/Q28586>,
	1240	<http://purl.uniprot.org/uniprot/Q62575>,
	1241	<http://purl.uniprot.org/uniprot/Q64H34>,
	1242	<http://purl.uniprot.org/uniprot/Q95J76>,
	1243	<http://purl.uniprot.org/uniprot/Q9BDS8>,
	1244	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1245	<http://purl.uniprot.org/uniprot/Q9XT91>,
	1246	<http://purl.uniprot.org/uniprot/Q9Z2I3>].
	1247
	1248	[ a sioc:Item ;
	1249	sioc:content "Increased levels of IL-5 receptor alpha and lymphocyte IL-5 production after anti- IL-5 therapy suggest an endogenous IL-5 autoregulatory pathway" ;
	1250	sioc:topic
	1251	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	1252	<http://purl.uniprot.org/uniprot/O02699>,
	1253	<http://purl.uniprot.org/uniprot/O08987>,
	1254	<http://purl.uniprot.org/uniprot/O77515>,
	1255	<http://purl.uniprot.org/uniprot/P04401>,
	1256	<http://purl.uniprot.org/uniprot/P05113>,
	1257	<http://purl.uniprot.org/uniprot/P46685>,
	1258	<http://purl.uniprot.org/uniprot/P48093>,
	1259	<http://purl.uniprot.org/uniprot/P52173>,
	1260	<http://purl.uniprot.org/uniprot/Q08125>,
	1261	<http://purl.uniprot.org/uniprot/Q28586>,
	1262	<http://purl.uniprot.org/uniprot/Q62575>,
	1263	<http://purl.uniprot.org/uniprot/Q95J76>,
	1264	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1265	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1266
	1267	[ a sioc:Item ;
	1268	sioc:content "We generated interleukin-5 receptor alpha chain (IL-5R alpha)-deficient (IL-5R alpha -/-) mice by gene targeting" ;
	1269	sioc:topic <http://purl.org/obo/owl/CHEBI#CHEBI_30216>, <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	1270
	1271	[ a sioc:Item ;
	1272	sioc:content "The IL-5R alpha -/- mice showed decreased numbers of B-1 cells concomitant with low serum concentrations of IgM and IgG3" ;
	1273	sioc:topic <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	1274
	1275	[ a sioc:Item ;
	1276	sioc:content "They showed no IL-5 -induced enhancement of B cell responses to T-independent antigens" ;
	1277	sioc:topic
	1278	<http://purl.uniprot.org/uniprot/O02699>,
	1279	<http://purl.uniprot.org/uniprot/O08987>,
	1280	<http://purl.uniprot.org/uniprot/O77515>,
	1281	<http://purl.uniprot.org/uniprot/P04401>,
	1282	<http://purl.uniprot.org/uniprot/P05113>,
	1283	<http://purl.uniprot.org/uniprot/P46685>,
	1284	<http://purl.uniprot.org/uniprot/P48093>,
	1285	<http://purl.uniprot.org/uniprot/P52173>,
	1286	<http://purl.uniprot.org/uniprot/Q08125>,
	1287	<http://purl.uniprot.org/uniprot/Q28586>,
	1288	<http://purl.uniprot.org/uniprot/Q62575>,
	1289	<http://purl.uniprot.org/uniprot/Q95J76>,
	1290	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1291	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1292
	1293	[ a sioc:Item ;
	1294	sioc:content "The number of alpha beta T cell receptor-positive thymocytes tended to decrease in 3- week-old IL-5R alpha -/- mice, returning to normal by 6 weeks of age" ;
	1295	sioc:topic
	1296	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	1297	<http://purl.uniprot.org/uniprot/P07700>,
	1298	<http://purl.uniprot.org/uniprot/P21183>,
	1299	<http://purl.uniprot.org/uniprot/Q01344>].
	1300
	1301	[ a sioc:Item ;
	1302	sioc:content "The IL-5R alpha -/- mice produced basal levels of eosinophils, while their bone marrow cells failed to form eosinophilic colonies in response to IL-5" ;
	1303	sioc:topic
	1304	<http://purl.uniprot.org/uniprot/O02699>,
	1305	<http://purl.uniprot.org/uniprot/O08987>,
	1306	<http://purl.uniprot.org/uniprot/O77515>,
	1307	<http://purl.uniprot.org/uniprot/P04401>,
	1308	<http://purl.uniprot.org/uniprot/P05113>,
	1309	<http://purl.uniprot.org/uniprot/P21183>,
	1310	<http://purl.uniprot.org/uniprot/P46685>,
	1311	<http://purl.uniprot.org/uniprot/P48093>,
	1312	<http://purl.uniprot.org/uniprot/P52173>,
	1313	<http://purl.uniprot.org/uniprot/Q01344>,
	1314	<http://purl.uniprot.org/uniprot/Q08125>,
	1315	<http://purl.uniprot.org/uniprot/Q28586>,
	1316	<http://purl.uniprot.org/uniprot/Q62575>,
	1317	<http://purl.uniprot.org/uniprot/Q95J76>,
	1318	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1319	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1320
	1321	[ a sioc:Item ;
	1322	sioc:content "The unique role of interleukin (IL)-5 in eosinophil production, activation, and localization makes this cytokine a prime target for therapeutic intervention in diseases characterized by a selective blood and tissue eosinophilia" ;
	1323	sioc:topic <http://purl.org/obo/owl/GO#GO_0051179>, <http://purl.org/obo/owl/REX#REX_0000221>].
	1324
	1325	[ a sioc:Item ;
	1326	sioc:content "Impaired eosinophilopoiesis in IL-5R alpha -/- mice enhanced the survival of Angiostrongylus cantonensis" ;
	1327	sioc:topic <http://purl.uniprot.org/uniprot/P21183>, <http://purl.uniprot.org/uniprot/Q01344>].
	1328
	1329	[ a sioc:Item ;
	1330	sioc:content "These results indicate that IL-5 -induced eosinophils serve as potent effector cells in the killing of Angiostrongylus cantonensis in mice" ;
	1331	sioc:topic
	1332	<http://purl.org/obo/owl/CHEBI#CHEBI_35224>,
	1333	<http://purl.uniprot.org/uniprot/O02699>,
	1334	<http://purl.uniprot.org/uniprot/O08987>,
	1335	<http://purl.uniprot.org/uniprot/O77515>,
	1336	<http://purl.uniprot.org/uniprot/P04401>,
	1337	<http://purl.uniprot.org/uniprot/P05113>,
	1338	<http://purl.uniprot.org/uniprot/P46685>,
	1339	<http://purl.uniprot.org/uniprot/P48093>,
	1340	<http://purl.uniprot.org/uniprot/P52173>,
	1341	<http://purl.uniprot.org/uniprot/Q08125>,
	1342	<http://purl.uniprot.org/uniprot/Q28586>,
	1343	<http://purl.uniprot.org/uniprot/Q62575>,
	1344	<http://purl.uniprot.org/uniprot/Q95J76>,
	1345	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1346	<http://purl.uniprot.org/uniprot/Q9XT91>].
	1347
	1348	[ a sioc:Item ;
	1349	sioc:content "In an attempt to block the effects of IL-5 on eosinophils, a strategy was developed to suppress the expression of the IL-5 receptor alpha chain (IL-5Ralpha) by antisense oligonucleotides (ASOs)" ;
	1350	sioc:topic
	1351	<http://purl.org/obo/owl/CHEBI#CHEBI_30216>,
	1352	<http://purl.org/obo/owl/CHEBI#CHEBI_30430>,
	1353	<http://purl.uniprot.org/uniprot/O02699>,
	1354	<http://purl.uniprot.org/uniprot/O08987>,
	1355	<http://purl.uniprot.org/uniprot/O77515>,
	1356	<http://purl.uniprot.org/uniprot/P04401>,
	1357	<http://purl.uniprot.org/uniprot/P05113>,
	1358	<http://purl.uniprot.org/uniprot/P14133>,
	1359	<http://purl.uniprot.org/uniprot/P21183>,
	1360	<http://purl.uniprot.org/uniprot/P24792>,
	1361	<http://purl.uniprot.org/uniprot/P37064>,
	1362	<http://purl.uniprot.org/uniprot/P46685>,
	1363	<http://purl.uniprot.org/uniprot/P48093>,
	1364	<http://purl.uniprot.org/uniprot/P52173>,
	1365	<http://purl.uniprot.org/uniprot/Q01344>,
	1366	<http://purl.uniprot.org/uniprot/Q08125>,
	1367	<http://purl.uniprot.org/uniprot/Q28586>,
	1368	<http://purl.uniprot.org/uniprot/Q40588>,
	1369	<http://purl.uniprot.org/uniprot/Q62575>,
	1370	<http://purl.uniprot.org/uniprot/Q95J76>,
	1371	<http://purl.uniprot.org/uniprot/Q9ESI9>,
	1372	<http://purl.uniprot.org/uniprot/Q9XT91>].